課程名稱 |
後生遺傳學概論 INTRODUCTION TO EPIGENETICS |
開課學期 |
96-1 |
授課對象 |
生物資源暨農學院 生物科技研究所 |
授課教師 |
林劭品 |
課號 |
Biot |
課程識別碼 |
642 U0020 |
班次 |
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學分 |
2 |
全/半年 |
半年 |
必/選修 |
必修 |
上課時間 |
星期四7,8(14:20~16:20) |
上課地點 |
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備註 |
限學士班三年級以上 總人數上限:30人 外系人數限制:15人 |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
課程大綱
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課程概述 |
Depends on the background of the students, around 2/3-3/4 of the lectures will be given by the instructor for introducing basic concepts in Epigenetic regulation of gene activity, including DNA methylation, modification of chromatin packaging proteins and functional non-coding RNAs. These will cover the physiological process including Genomic Imprinting, Sex Chromosome Compensation, Silencing of Endogenous Retrotransposons and Newly Infected Viral Sequences, Stem Cell Biology in the introductory level. In addition, the involvement of Epigenetic Regulatory Mechanisms in Carcinogenesis, Animal Cloning, Reprogramming and Regenerative Medicine will be discussed. For the rest of the classes, students will be assigned the most updated original research papers as well as the milestone publications. They will be randomly divided into 2 groups for each assignment. One group will be presenting the articles and students in the other group are expected to challenge the papers from the experimental design, the methodology to the interpretation of the data. Students in the 1st group should defend for the papers as if it’s their manuscript. Students from the 2nd group should also provide constructive advice as how to improve the manuscript so that it can be published in a higher impact journal. |
課程目標 |
On top of learning the basic concepts in Epigenetic, and the various physiological processes and disease syndrome that are controlled/caused by Epigenetic Regulatory Mechanisms, students are expected to develop the ability to critically evaluate and interpret published research articles. |
課程要求 |
Preferably having backgrounds in one of the following subjects: Biochemistry, Cell Biology, Genetics, Molecular Biology or Epigenetics |
預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
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參考書目 |
Updated journal articles and reviews; “Epigenetics: Concepts, Theories, Paradigms and Mechanisms” and “Stem cell and Regenerative Medicine” CD-Roms (The Henry Stewart Talks Series in the Life Sciences) |
評量方式 (僅供參考) |
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